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Ghanaian quinine is a shrub containing a chemical that is used to treat malaria, hepatitis and tuberculosis in West Africa. Researchers at Johns Hopkins university studied 14 plant-based extracts and compared their effectiveness against doxycycline and cefuroxime, two antibiotics used to … The disease spreads to humans through the bite of a tick that carries the bacterium, and it affects an estimated 300,000 people each year in the U.S. alone. Lyme disease — transmitted via tick bite — affects thousands of people in the United States and around the world. Ghanaian Quinine Completely Eliminated Lyme Disease bacteria in vitro Ghanaian Quinine Completely Eliminated Lyme Disease bacteria in vitro Remarkably, a single 7-day treatment with 1% Ghanaian quinine could completely eradicate the bacterium - it did not regrow, even under optimal conditions in the drug's absence. The plants in question were black walnut (Juglans nigra), cat’s claw (Uncaria tomentosa), sweet wormwood (Artemisia annua), Mediterranean rockrose (Cistus incanus), Chinese skullcap (Scutellaria baicalensis), Ghanaian quinine (Cryptolepis sanguinolenta), and Japanese knotweed (Polygonum cuspidatum). The discovery of novel treatments against Lyme disease is therefore of great interest. A single 7-day treatment with Ghanaian quinine completely eradicated the bacterium. Japanese knotweed is a traditional medicine in India and China that contains the polyphenol resveratrol. In 2018, an in vitro (in culture cells) study suggested that 10 plant-derived essential oils could help fight off B. burgdorferi. We are interested in further evaluating these potent herbal medicines through animal studies as well as clinical trials.”. Ghanaian quinine is a shrub from West Africa containing the antimicrobial alkaloid cryptolepine, and is used in ethnomedicine to treat malaria, hepatitis, septicemia, and tuberculosis. Japanese knotweed is a traditional medicine in India and China that contains the polyphenol resveratrol. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional, Complementary Medicine / Alternative Medicine, Eating dried fruit linked to better overall diet and health, Loneliness and hunger share a home in the brain, Tuberculosis vaccine may help protect against COVID-19, Jaw-clenching and teeth-grinding during the pandemic, The impact of historical trauma on American Indian health equity, Lyme disease and rheumatoid arthritis: What you need to know, Chronic Lyme disease: Everything you need to know. All rights reserved. Unless otherwise noted, you can republish articles posted in the Frontiers news blog — as long as you include a link back to the original research. In their study — whose findings appear in the journal Frontiers in Medicine — the investigators analyzed the potential of 14 different plant extracts in killing B. burgdorferi. The University of Southampton has joined the Frontiers – JISC national open access deal. Learn more…, Lyme disease is commonly caused by ticks. Ghanaian quinine is a shrub from West Africa containing the antimicrobial alkaloid cryptolepine, and is used in ethnomedicine to treat malaria, hepatitis, septicemia, and tuberculosis. “This study provides the first convincing evidence that some of the herbs used by patients such as Cryptolepis, black walnut, sweet wormwood, cat’s claw, and Japanese knotweed have potent activity against Lyme disease bacteria, especially the dormant persister forms, which are not killed by the current Lyme antibiotics,” says Dr Ying Zhang from the Johns Hopkins Bloomberg School of Public Health. In fact, just one 7-day treatment with 1% Ghanaian quinine extract was able to eradicate the bacterium in lab dishes. Babesia and Lyme disease: What's the connection. The active ingredient in Ghanaian quinine is an alkaloid called cryptolepine, which people have traditionally used against malaria, hepatitis, septicemia, and tuberculosis. Selling the articles is not allowed. Japanese knotweed and Ghanaian quinine were found to be anti-inflammatory Japanese knotweed may be more effective than antibiotics at tackling Lyme disease, new study has found. But further preclinical studies and clinical trials will be required to establish evidence for effective treatment of Lyme disease patients.”This research was supported by the Bay Area Lyme Foundation and the Steven & Alexandra Cohen Foundation. Lyme disease is an infectious disease caused by the bacterium Borrelia burgdorferi (B. burgdorferi). Ghanaian quinine is a shrub from West Africa containing the antimicrobial alkaloid cryptolepine and is used in ethnomedicine to treat malaria, hepatitis, septicemia, and tuberculosis. The researchers note that the ones with the highest antibacterial activity directed against B. burgdorferi were Ghanaian quinine and Japanese knotweed. Ghanaian quinine is a shrub from West Africa containing the antimicrobial alkaloid cryptolepine, and is used in ethnomedicine to treat malaria, hepatitis, septicemia, and tuberculosis. This was the case with extracts from grapefruit seeds, green chiretta (Andrographis paniculata), ashwagandha, stevia, fuller’s teasel (Dipsacus fullonum), and Japanese teasel. Both plants were found to kill microcolonies of B. burgdorferi and inhibit division of the planktonic form, even at low concentrations. Extracts of grapefruit seeds, green chiretta, ashwagandha, candy leaf (also known as stevia), fuller’s teasel, and Japanese teasel had little or no effect, and neither did the chemicals colloidal silver, monoglyceride monolaurin, or antimicrobial peptide LL37 from human immune cells. Discussion New studies on using Ghanaian quinine and Japanese Knotweed to treat Lyme's? At the same time, some of the other natural compounds that the researchers tested offered insignificant or no results. Click to share on Twitter (Opens in new window), Click to share on Facebook (Opens in new window), Click to share on LinkedIn (Opens in new window), Click to share on Reddit (Opens in new window), Click to share on Pinterest (Opens in new window), Click to share on WhatsApp (Opens in new window), Click to email this to a friend (Opens in new window), An innovative new diagnostic for Lyme disease, Evaluation of Natural and Botanical Medicines for Activity against Growing and Non-growing Forms of B. burgdorferi. The researchers tested these extracts’ effectiveness in vitro (outside of a living organism) against the free-swimming “planktonic” form of the bacterium as well as against microcolonies. Find out about symptoms, treatment, and how to reduce the risk. While the current findings indicate that many plants hold promise in the treatment of Lyme disease, the researchers caution that studies in animals and humans are still necessary to confirm the natural remedies’ efficacy and safety. Japanese knotweed, an Asian traditional medicine, contains polyphenol resveratrol which is found to have anti-tumour and anti-inflammatory effects and protects the nervous system and heart. These were colloidal silver, monoglyceride monolaurin, and the antimicrobial peptide LL37 — also found human immune cells. ILLUSTRATION: Beginner’s Guide to Peer Review, Frontiers’ volunteers: “I learnt to use a hoe like a pro!”. The active ingredient in Ghanaian quinine is an alkaloid called cryptolepine, which people have traditionally used against malaria, hepatitis, septicemia, and tuberculosis. In other preclinical studies it has been found to have anti-tumor and anti-inflammatory effects and protect the nervous system and heart. Posts about Japanese knotweed written by Ralph Turchiano. “Many thousands of Lyme patients today, especially those with later-stage symptoms who have not been effectively treated, are in great need of efficacious, accessible treatment options,” says Dr Sunjya K. Schweig, CEO and co-Director of the California Center for Functional Medicine and Scientific Advisory Board Member of the Bay Area Lyme Foundation. Remarkably, a single 7-day treatment with 1% Ghanaian quinine could completely eradicate the bacterium – it did not regrow, even under optimal conditions in the drug’s absence. Nervous system and cause joint pain and swelling one 7-day treatment with Ghanaian quinine and japanese knotweed is traditional! Suggested that resveratrol may have anticancer properties, and how to reduce the.! The world quinine extract was able to eradicate the bacterium extract was able to the... 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